Are you feeling overwhelmed by anxiety and looking for a solution? Two commonly prescribed medications, Alprazolam (Xanax) and Clonazepam (Klonopin), might be the answer you’re looking for. Let’s dive deeper into these two drugs and find out which one might suit your needs better.
Forms Available
When it comes to the forms available, Klonopin offers a range of options. It comes in 0.5mg, 1mg, and 2mg tablets, as well as 0.125mg, 0.25mg, 0.5mg, 1mg, and 2mg disintegrating tablets. On the other hand, Xanax is available in 0.25mg, 0.5mg, 1mg, and 2mg tablets. The 2mg tablets of Xanax are multi-scored and can be divided if needed.
Effect
Both Klonopin and Xanax work by increasing the effect of gamma-aminobutyric acid (GABA) in the brain, which helps to calm the nervous system. As a result, they can potentially cause drowsiness or sedation.
How Klonopin Works
To better understand how Klonopin or Clonazepam works, take a look at this video that explains its mechanism and how it helps people with epilepsy.
How Xanax Works
Curious about how Xanax or Alprazolam works? Let’s find out!
Uses
Klonopin is primarily prescribed for epilepsy but can also be used to treat panic disorder, seizures, anxiety disorders, parasomnia, OCD, and clinical depression. On the other hand, Xanax is commonly used to treat anxiety disorders, panic disorders, and anxiety associated with depression.
Effectiveness
The effectiveness of Klonopin and Xanax may vary from person to person. However, a study conducted by Massachusetts General Hospital in 1991 found that both medications were equally effective in treating panic disorders [1].
Scientific Studies
Here are some noteworthy scientific studies that provide useful information on the effects of Xanax and Klonopin:
- A 1997 study discovered that Alprazolam (Xanax) increases physiological activation (heart rate, respiratory rate) under acute stress conditions and can hinder the therapeutic effects of exposure in flying phobia. In other words, Xanax may not always help individuals with a fear of flying.
- A study published in 2011 explored the effects of Clonazepam (Klonopin) and Alprazolam (Xanax) and concluded that short-term chronic administration of Xanax could potentially have more adverse effects on the immune system and blood vessels compared to Klonopin, especially under stressful conditions.
- Co-administration with Prozac (Fluoxetine): A 1992 research study found that when Xanax is combined with Prozac, it prolongs the half-life of Xanax and impairs its clearance. Klonopin does not have a similar effect.
- A 1988 study suggested that it is possible to substitute Clonazepam for Alprazolam when patients become dependent on the latter.
- A study conducted in 2000 examined medical records from 1989 and 1990 to determine whether Xanax or Klonopin caused an increase in problematic behaviors such as self-injury or assault. The study concluded that the risk of such behaviors was no different than when a placebo was administered.
Dosage
For Klonopin, it is important not to exceed a duration of more than 9 weeks without a doctor’s advice. Higher doses of Klonopin (more than 0.5 – 1 mg per day) are associated with significant sedation.
As for Xanax, the initial dosage for adults with anxiety disorders is usually between 0.25mg and 0.5mg, three times daily. This dose can be gradually increased up to 4mg in divided doses. It is important to decrease the dosage gradually when discontinuing.
Side Effects
Both Klonopin and Xanax have common side effects that include drowsiness, dizziness, memory problems, and blurred vision, among others. However, there are also some more serious side effects associated with these medications. If you experience any of these serious side effects, it is important to seek medical attention immediately.
Restrictions
There are certain restrictions for using Klonopin and Xanax. Klonopin should not be used by individuals with severe liver disease, narrow-angle glaucoma, or allergies to other benzodiazepines. It is also important to avoid mixing Klonopin with alcohol.
Similarly, Xanax should not be used by individuals allergic to benzodiazepines, pregnant women, those with narrow-angle glaucoma, and those taking Sporanix or Nizoral. Mixing Xanax with alcohol is also strongly advised against.
Withdrawal
Both Klonopin and Xanax have the potential for withdrawal symptoms if the dosage is suddenly reduced or discontinued abruptly. It is recommended to decrease the dosage gradually under medical supervision to avoid potential withdrawal symptoms such as anxiety, irritability, insomnia, tremors, seizures, and exacerbated panic disorder.
Abuse
Unfortunately, both Klonopin and Xanax are prone to abuse. Prolonged and excessive use of these medications can lead to dependency and abuse. If you notice any signs of abuse, it is important to seek help. Signs of abuse include using the medication daily, always having it on hand, feeling the need to take it to function, being willing to break the law to acquire it, taking it without a medical reason, and requiring higher doses for the same effect as before. Klonopin is the second most frequently used benzodiazepine that leads to emergency department visits, including cases of drug abuse, overdose, and adverse reactions.
References
[1] Double-blind, placebo-controlled comparison of clonazepam and alprazolam for panic disorder – NIHRemember, always consult with a healthcare professional before starting or changing any medication. Your doctor will be the best source of information and guidance tailored to your specific needs. Stay safe and take care!
